AustralieFrV1, Main, Exploration, bibRecord, 001268

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.

Identifieur interne : 001268 ( Main/Exploration ); précédent : 001267; suivant : 001269

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.

Auteurs : Lucila Sackmann Sala [France] ; Florence Boutillon [France] ; Giulia Menara [France] ; Andréa De Goyon-Pélard [France] ; Mylène Leprévost [France] ; Julie Codzamanian [France] ; Natalie Lister [Australie] ; Jan Pencik [Autriche] ; Ashlee Clark [Australie] ; Nicolas Cagnard [France] ; Christine Bole-Feysot [France] ; Richard Moriggl [Autriche] ; Gail P. Risbridger [Australie] ; Renea A. Taylor [Australie] ; Lukas Kenner [Autriche] ; Jacques-Emmanuel Guidotti [France] ; Vincent Goffin [France]

Source :

The Journal of pathology [ 1096-9896 ] ; 2017.

RBID : pubmed:28603917

Descripteurs français

English descriptors

KwdEn :
- Androgen Antagonists (pharmacology), Animals, Antineoplastic Agents, Hormonal (pharmacology), Ataxin-1 (metabolism), Biomarkers, Tumor (deficiency), Biomarkers, Tumor (genetics), Cell Lineage, Cell Proliferation (drug effects), Drug Resistance, Neoplasm, Gene Expression Profiling (methods), Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Integrin alpha6 (metabolism), Keratin-4 (metabolism), Male, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Recurrence, Local, Neoplastic Stem Cells (drug effects), Neoplastic Stem Cells (enzymology), Neoplastic Stem Cells (pathology), Neoplastic Stem Cells (transplantation), Oligonucleotide Array Sequence Analysis, PTEN Phosphohydrolase (deficiency), PTEN Phosphohydrolase (genetics), Phenotype, Prostatic Neoplasms, Castration-Resistant (drug therapy), Prostatic Neoplasms, Castration-Resistant (enzymology), Prostatic Neoplasms, Castration-Resistant (genetics), Prostatic Neoplasms, Castration-Resistant (pathology), Receptors, Androgen (drug effects), Receptors, Androgen (metabolism), Signal Transduction.
MESH :
- chemical , deficiency : Biomarkers, Tumor, PTEN Phosphohydrolase.
- chemical , drug effects : Receptors, Androgen.
- chemical , genetics : Biomarkers, Tumor, PTEN Phosphohydrolase.
- chemical , metabolism : Ataxin-1, Integrin alpha6, Keratin-4, Receptors, Androgen.
- chemical , pharmacology : Androgen Antagonists, Antineoplastic Agents, Hormonal.
- drug effects : Cell Proliferation, Neoplastic Stem Cells.
- drug therapy : Prostatic Neoplasms, Castration-Resistant.
- enzymology : Neoplastic Stem Cells, Prostatic Neoplasms, Castration-Resistant.
- genetics : Prostatic Neoplasms, Castration-Resistant.
- methods : Gene Expression Profiling.
- pathology : Neoplastic Stem Cells, Prostatic Neoplasms, Castration-Resistant.
- transplantation : Neoplastic Stem Cells.
- Animals, Cell Lineage, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Male, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Recurrence, Local, Oligonucleotide Array Sequence Analysis, Phenotype, Signal Transduction.

Abstract

Castration-resistant prostate cancer is a lethal disease. The cell type(s) that survive androgen deprivation remain poorly described, despite global efforts to understand the various mechanisms of therapy resistance. We recently identified in wild-type (WT) mouse prostates a rare population of luminal progenitor cells that we called LSC(med) according to their FACS profile (Lin(-) /Sca-1(+) /CD49f(med) ). Here, we investigated the prevalence and castration resistance of LSC(med) in various mouse models of prostate tumourigenesis (Pb-PRL, Pten(pc-/-) , and Hi-Myc mice). LSC(med) prevalence is low (∼8%, similar to WT) in Hi-Myc mice, where prostatic androgen receptor signalling is unaltered, but is significantly higher in the two other models, where androgen receptor signalling is decreased, rising up to more than 80% in Pten(pc-/-) prostates. LSC(med) tolerate androgen deprivation and persist or are enriched 2-3 weeks after castration. The tumour-initiating properties of LSC(med) from Pten(pc-/-) mice were demonstrated by regeneration of tumours in vivo. Transcriptomic analysis revealed that LSC(med) represent a unique cell entity as their gene expression profile is different from luminal and basal/stem cells, but shares markers of each. Their intrinsic androgen signalling is markedly decreased, explaining why LSC(med) tolerate androgen deprivation. This also illuminates why Pten(pc-/-) tumours are castration-resistant since LSC(med) represent the most prevalent cell type in this model. We validated CK4 as a specific marker for LSC(med) on sorted cells and prostate tissues by immunostaining, allowing for the detection of LSC(med) in various mouse prostate specimens. In castrated Pten(pc-/-) prostates, there was significant proliferation of CK4(+) cells, further demonstrating their key role in castration-resistant prostate cancer progression. Taken together, this study identifies LSC(med) as a probable source of prostate cancer relapse after androgen deprivation and as a new therapeutic target for the prevention of castrate-resistant prostate cancer. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

DOI: 10.1002/path.4924
PubMed: 28603917

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.</title>
<author><name sortKey="Sackmann Sala, Lucila" sort="Sackmann Sala, Lucila" uniqKey="Sackmann Sala L" first="Lucila" last="Sackmann Sala">Lucila Sackmann Sala</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boutillon, Florence" sort="Boutillon, Florence" uniqKey="Boutillon F" first="Florence" last="Boutillon">Florence Boutillon</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menara, Giulia" sort="Menara, Giulia" uniqKey="Menara G" first="Giulia" last="Menara">Giulia Menara</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Goyon Pelard, Andrea" sort="De Goyon Pelard, Andrea" uniqKey="De Goyon Pelard A" first="Andréa" last="De Goyon-Pélard">Andréa De Goyon-Pélard</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leprevost, Mylene" sort="Leprevost, Mylene" uniqKey="Leprevost M" first="Mylène" last="Leprévost">Mylène Leprévost</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Codzamanian, Julie" sort="Codzamanian, Julie" uniqKey="Codzamanian J" first="Julie" last="Codzamanian">Julie Codzamanian</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lister, Natalie" sort="Lister, Natalie" uniqKey="Lister N" first="Natalie" last="Lister">Natalie Lister</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pencik, Jan" sort="Pencik, Jan" uniqKey="Pencik J" first="Jan" last="Pencik">Jan Pencik</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Clinical Institute of Pathology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clark, Ashlee" sort="Clark, Ashlee" uniqKey="Clark A" first="Ashlee" last="Clark">Ashlee Clark</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cagnard, Nicolas" sort="Cagnard, Nicolas" uniqKey="Cagnard N" first="Nicolas" last="Cagnard">Nicolas Cagnard</name>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bioinformatics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bole Feysot, Christine" sort="Bole Feysot, Christine" uniqKey="Bole Feysot C" first="Christine" last="Bole-Feysot">Christine Bole-Feysot</name>
<affiliation wicri:level="3"><nlm:affiliation>Genomics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genomics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moriggl, Richard" sort="Moriggl, Richard" uniqKey="Moriggl R" first="Richard" last="Moriggl">Richard Moriggl</name>
<affiliation wicri:level="3"><nlm:affiliation>Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Renea A" sort="Taylor, Renea A" uniqKey="Taylor R" first="Renea A" last="Taylor">Renea A. Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kenner, Lukas" sort="Kenner, Lukas" uniqKey="Kenner L" first="Lukas" last="Kenner">Lukas Kenner</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Clinical Institute of Pathology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guidotti, Jacques Emmanuel" sort="Guidotti, Jacques Emmanuel" uniqKey="Guidotti J" first="Jacques-Emmanuel" last="Guidotti">Jacques-Emmanuel Guidotti</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goffin, Vincent" sort="Goffin, Vincent" uniqKey="Goffin V" first="Vincent" last="Goffin">Vincent Goffin</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28603917</idno>
<idno type="pmid">28603917</idno>
<idno type="doi">10.1002/path.4924</idno>
<idno type="wicri:Area/PubMed/Corpus">000546</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000546</idno>
<idno type="wicri:Area/PubMed/Curation">000544</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000544</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000544</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000544</idno>
<idno type="wicri:Area/Ncbi/Merge">004964</idno>
<idno type="wicri:Area/Ncbi/Curation">004964</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004964</idno>
<idno type="wicri:Area/Main/Merge">001263</idno>
<idno type="wicri:Area/Main/Curation">001268</idno>
<idno type="wicri:Area/Main/Exploration">001268</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.</title>
<author><name sortKey="Sackmann Sala, Lucila" sort="Sackmann Sala, Lucila" uniqKey="Sackmann Sala L" first="Lucila" last="Sackmann Sala">Lucila Sackmann Sala</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boutillon, Florence" sort="Boutillon, Florence" uniqKey="Boutillon F" first="Florence" last="Boutillon">Florence Boutillon</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menara, Giulia" sort="Menara, Giulia" uniqKey="Menara G" first="Giulia" last="Menara">Giulia Menara</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Goyon Pelard, Andrea" sort="De Goyon Pelard, Andrea" uniqKey="De Goyon Pelard A" first="Andréa" last="De Goyon-Pélard">Andréa De Goyon-Pélard</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leprevost, Mylene" sort="Leprevost, Mylene" uniqKey="Leprevost M" first="Mylène" last="Leprévost">Mylène Leprévost</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Codzamanian, Julie" sort="Codzamanian, Julie" uniqKey="Codzamanian J" first="Julie" last="Codzamanian">Julie Codzamanian</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lister, Natalie" sort="Lister, Natalie" uniqKey="Lister N" first="Natalie" last="Lister">Natalie Lister</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pencik, Jan" sort="Pencik, Jan" uniqKey="Pencik J" first="Jan" last="Pencik">Jan Pencik</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Clinical Institute of Pathology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clark, Ashlee" sort="Clark, Ashlee" uniqKey="Clark A" first="Ashlee" last="Clark">Ashlee Clark</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cagnard, Nicolas" sort="Cagnard, Nicolas" uniqKey="Cagnard N" first="Nicolas" last="Cagnard">Nicolas Cagnard</name>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bioinformatics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bole Feysot, Christine" sort="Bole Feysot, Christine" uniqKey="Bole Feysot C" first="Christine" last="Bole-Feysot">Christine Bole-Feysot</name>
<affiliation wicri:level="3"><nlm:affiliation>Genomics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genomics Core Facility, Inserm US 24-CNRS UMS 3633-SFR Necker, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moriggl, Richard" sort="Moriggl, Richard" uniqKey="Moriggl R" first="Richard" last="Moriggl">Richard Moriggl</name>
<affiliation wicri:level="3"><nlm:affiliation>Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Renea A" sort="Taylor, Renea A" uniqKey="Taylor R" first="Renea A" last="Taylor">Renea A. Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Partners Comprehensive Cancer Consortium and Cancer Program, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Departments of Physiology and Anatomy and Developmental Biology, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kenner, Lukas" sort="Kenner, Lukas" uniqKey="Kenner L" first="Lukas" last="Kenner">Lukas Kenner</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Clinical Institute of Pathology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guidotti, Jacques Emmanuel" sort="Guidotti, Jacques Emmanuel" uniqKey="Guidotti J" first="Jacques-Emmanuel" last="Guidotti">Jacques-Emmanuel Guidotti</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goffin, Vincent" sort="Goffin, Vincent" uniqKey="Goffin V" first="Vincent" last="Goffin">Vincent Goffin</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of pathology</title>
<idno type="eISSN">1096-9896</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Androgen Antagonists (pharmacology)</term>
<term>Animals</term>
<term>Antineoplastic Agents, Hormonal (pharmacology)</term>
<term>Ataxin-1 (metabolism)</term>
<term>Biomarkers, Tumor (deficiency)</term>
<term>Biomarkers, Tumor (genetics)</term>
<term>Cell Lineage</term>
<term>Cell Proliferation (drug effects)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Gene Expression Profiling (methods)</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Genetic Predisposition to Disease</term>
<term>Integrin alpha6 (metabolism)</term>
<term>Keratin-4 (metabolism)</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplastic Stem Cells (drug effects)</term>
<term>Neoplastic Stem Cells (enzymology)</term>
<term>Neoplastic Stem Cells (pathology)</term>
<term>Neoplastic Stem Cells (transplantation)</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>PTEN Phosphohydrolase (deficiency)</term>
<term>PTEN Phosphohydrolase (genetics)</term>
<term>Phenotype</term>
<term>Prostatic Neoplasms, Castration-Resistant (drug therapy)</term>
<term>Prostatic Neoplasms, Castration-Resistant (enzymology)</term>
<term>Prostatic Neoplasms, Castration-Resistant (genetics)</term>
<term>Prostatic Neoplasms, Castration-Resistant (pathology)</term>
<term>Receptors, Androgen (drug effects)</term>
<term>Receptors, Androgen (metabolism)</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes ()</term>
<term>Animaux</term>
<term>Antagonistes des androgènes (pharmacologie)</term>
<term>Antinéoplasiques hormonaux (pharmacologie)</term>
<term>Ataxine-1 (métabolisme)</term>
<term>Cellules souches tumorales ()</term>
<term>Cellules souches tumorales (anatomopathologie)</term>
<term>Cellules souches tumorales (enzymologie)</term>
<term>Cellules souches tumorales (transplantation)</term>
<term>Intégrine alpha6 (métabolisme)</term>
<term>Kératine-4 (métabolisme)</term>
<term>Lignage cellulaire</term>
<term>Marqueurs biologiques tumoraux (déficit)</term>
<term>Marqueurs biologiques tumoraux (génétique)</term>
<term>Mâle</term>
<term>Phosphohydrolase PTEN (déficit)</term>
<term>Phosphohydrolase PTEN (génétique)</term>
<term>Phénotype</term>
<term>Prolifération cellulaire ()</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteurs aux androgènes ()</term>
<term>Récepteurs aux androgènes (métabolisme)</term>
<term>Récidive tumorale locale</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Séquençage par oligonucléotides en batterie</term>
<term>Transduction du signal</term>
<term>Tumeurs prostatiques résistantes à la castration (anatomopathologie)</term>
<term>Tumeurs prostatiques résistantes à la castration (enzymologie)</term>
<term>Tumeurs prostatiques résistantes à la castration (génétique)</term>
<term>Tumeurs prostatiques résistantes à la castration (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>PTEN Phosphohydrolase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Androgen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>PTEN Phosphohydrolase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ataxin-1</term>
<term>Integrin alpha6</term>
<term>Keratin-4</term>
<term>Receptors, Androgen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Androgen Antagonists</term>
<term>Antineoplastic Agents, Hormonal</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules souches tumorales</term>
<term>Tumeurs prostatiques résistantes à la castration</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
<term>Neoplastic Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Prostatic Neoplasms, Castration-Resistant</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term>
<term>Phosphohydrolase PTEN</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules souches tumorales</term>
<term>Tumeurs prostatiques résistantes à la castration</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neoplastic Stem Cells</term>
<term>Prostatic Neoplasms, Castration-Resistant</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Prostatic Neoplasms, Castration-Resistant</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term>
<term>Phosphohydrolase PTEN</term>
<term>Tumeurs prostatiques résistantes à la castration</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gene Expression Profiling</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ataxine-1</term>
<term>Intégrine alpha6</term>
<term>Kératine-4</term>
<term>Récepteurs aux androgènes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplastic Stem Cells</term>
<term>Prostatic Neoplasms, Castration-Resistant</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antagonistes des androgènes</term>
<term>Antinéoplasiques hormonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs prostatiques résistantes à la castration</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neoplastic Stem Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Lineage</term>
<term>Drug Resistance, Neoplasm</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Genetic Predisposition to Disease</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Neoplasm Recurrence, Local</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Phenotype</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Cellules souches tumorales</term>
<term>Lignage cellulaire</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Prolifération cellulaire</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteurs aux androgènes</term>
<term>Récidive tumorale locale</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Séquençage par oligonucléotides en batterie</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Castration-resistant prostate cancer is a lethal disease. The cell type(s) that survive androgen deprivation remain poorly described, despite global efforts to understand the various mechanisms of therapy resistance. We recently identified in wild-type (WT) mouse prostates a rare population of luminal progenitor cells that we called LSC(med) according to their FACS profile (Lin(-) /Sca-1(+) /CD49f(med) ). Here, we investigated the prevalence and castration resistance of LSC(med) in various mouse models of prostate tumourigenesis (Pb-PRL, Pten(pc-/-) , and Hi-Myc mice). LSC(med) prevalence is low (∼8%, similar to WT) in Hi-Myc mice, where prostatic androgen receptor signalling is unaltered, but is significantly higher in the two other models, where androgen receptor signalling is decreased, rising up to more than 80% in Pten(pc-/-) prostates. LSC(med) tolerate androgen deprivation and persist or are enriched 2-3 weeks after castration. The tumour-initiating properties of LSC(med) from Pten(pc-/-) mice were demonstrated by regeneration of tumours in vivo. Transcriptomic analysis revealed that LSC(med) represent a unique cell entity as their gene expression profile is different from luminal and basal/stem cells, but shares markers of each. Their intrinsic androgen signalling is markedly decreased, explaining why LSC(med) tolerate androgen deprivation. This also illuminates why Pten(pc-/-) tumours are castration-resistant since LSC(med) represent the most prevalent cell type in this model. We validated CK4 as a specific marker for LSC(med) on sorted cells and prostate tissues by immunostaining, allowing for the detection of LSC(med) in various mouse prostate specimens. In castrated Pten(pc-/-) prostates, there was significant proliferation of CK4(+) cells, further demonstrating their key role in castration-resistant prostate cancer progression. Taken together, this study identifies LSC(med) as a probable source of prostate cancer relapse after androgen deprivation and as a new therapeutic target for the prevention of castrate-resistant prostate cancer. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>France</li>
</country>
<region><li>Vienne (Autriche)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Sackmann Sala, Lucila" sort="Sackmann Sala, Lucila" uniqKey="Sackmann Sala L" first="Lucila" last="Sackmann Sala">Lucila Sackmann Sala</name>
</region>
<name sortKey="Bole Feysot, Christine" sort="Bole Feysot, Christine" uniqKey="Bole Feysot C" first="Christine" last="Bole-Feysot">Christine Bole-Feysot</name>
<name sortKey="Boutillon, Florence" sort="Boutillon, Florence" uniqKey="Boutillon F" first="Florence" last="Boutillon">Florence Boutillon</name>
<name sortKey="Cagnard, Nicolas" sort="Cagnard, Nicolas" uniqKey="Cagnard N" first="Nicolas" last="Cagnard">Nicolas Cagnard</name>
<name sortKey="Codzamanian, Julie" sort="Codzamanian, Julie" uniqKey="Codzamanian J" first="Julie" last="Codzamanian">Julie Codzamanian</name>
<name sortKey="De Goyon Pelard, Andrea" sort="De Goyon Pelard, Andrea" uniqKey="De Goyon Pelard A" first="Andréa" last="De Goyon-Pélard">Andréa De Goyon-Pélard</name>
<name sortKey="Goffin, Vincent" sort="Goffin, Vincent" uniqKey="Goffin V" first="Vincent" last="Goffin">Vincent Goffin</name>
<name sortKey="Guidotti, Jacques Emmanuel" sort="Guidotti, Jacques Emmanuel" uniqKey="Guidotti J" first="Jacques-Emmanuel" last="Guidotti">Jacques-Emmanuel Guidotti</name>
<name sortKey="Leprevost, Mylene" sort="Leprevost, Mylene" uniqKey="Leprevost M" first="Mylène" last="Leprévost">Mylène Leprévost</name>
<name sortKey="Menara, Giulia" sort="Menara, Giulia" uniqKey="Menara G" first="Giulia" last="Menara">Giulia Menara</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lister, Natalie" sort="Lister, Natalie" uniqKey="Lister N" first="Natalie" last="Lister">Natalie Lister</name>
</noRegion>
<name sortKey="Clark, Ashlee" sort="Clark, Ashlee" uniqKey="Clark A" first="Ashlee" last="Clark">Ashlee Clark</name>
<name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name>
<name sortKey="Taylor, Renea A" sort="Taylor, Renea A" uniqKey="Taylor R" first="Renea A" last="Taylor">Renea A. Taylor</name>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pencik, Jan" sort="Pencik, Jan" uniqKey="Pencik J" first="Jan" last="Pencik">Jan Pencik</name>
</region>
<name sortKey="Kenner, Lukas" sort="Kenner, Lukas" uniqKey="Kenner L" first="Lukas" last="Kenner">Lukas Kenner</name>
<name sortKey="Moriggl, Richard" sort="Moriggl, Richard" uniqKey="Moriggl R" first="Richard" last="Moriggl">Richard Moriggl</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001268 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001268 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28603917
   |texte=   A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28603917" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.